DxCodebookFY2027 · Oct 1, 2026 – Sep 30, 2027

Category · FY2027

E22 Hyperfunction of pituitary gland

  • Header · not billable

E22 is not billable. The category heads 5 billable codes in FY2027: the 5 codes directly below it.

Index → code

  • Hyperpituitarism → E22.9
  • Hyperprolactinemia → E22.1
  • Acromegaly, acromegalia → E22.0

Where it sits

  1. Chapter 4 Endocrine, nutritional and metabolic diseases (E00-E89)
  2. E20-E35 Disorders of other endocrine glands (E20-E35)
  3. E22 Hyperfunction of pituitary gland
Billable codes
5
Subdivisions
5
CC / MCC codes
4 / 0
HCC V28 codes
1
New FY2027
0
Index entries
40

Codes in E22

  1. E22.0
    Acromegaly and pituitary gigantism
    Billable51
    Inclusion terms 1, Excludes1 3

    Inclusion terms

    • Overproduction of growth hormone

    Excludes1

    • constitutional gigantism (E34.4) E34.4
    • constitutional tall stature (E34.4) E34.4
    • increased secretion from endocrine pancreas of growth hormone-releasing hormone (E16.8) E16.8
  2. E22.1
    Hyperprolactinemia
    BillableCC
    Use additional code 1

    Use additional code

    • code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5) T36 T50
  3. E22.2
    Syndrome of inappropriate secretion of antidiuretic hormone
    BillableCC
  4. E22.8
    Other hyperfunction of pituitary gland
    BillableCC
    Inclusion terms 1

    Inclusion terms

    • Central precocious puberty
  5. E22.9
    Hyperfunction of pituitary gland, unspecified
    BillableCC

CC/MCC: as a secondary diagnosis, unless the principal diagnosis is on the code’s PDX exclusion list (MS-DRG v44 Appendix C; list on the code card).

Sources of each column.

Instructions

At E22

Excludes1

  • Cushing's syndrome (E24.-) E24
  • Nelson's syndrome (E24.1) E24.1
  • overproduction of ACTH not associated with Cushing's disease (E27.0) E27.0
  • overproduction of pituitary ACTH (E24.0) E24.0
  • overproduction of thyroid-stimulating hormone (E05.8-) E05.8

Notes that also apply

Block E20-E35 instructions (Excludes1 2): printed on the block page.

Chapter 4 instructions (Notes 1, Excludes1 1): printed on the chapter 4 page.

Index entries

  • Acromegaly, acromegalia → E22.0
  • Erdheim's syndrome (acromegalic macrospondylitis) → E22.0
  • Gigantism (cerebral) (hypophyseal) (pituitary) → E22.0
  • Launois' syndrome (pituitary gigantism) → E22.0
  • Macrospondylitis , acromegalic → E22.0
  • Scaglietti-Dagnini syndrome → E22.0
  • Hyperprolactinemia → E22.1
  • Antidiuretic hormone syndrome → E22.2
  • Schwartz-Bartter syndrome → E22.2
  • Hyperpituitarism → E22.9
  • Hypophyseal, hypophysisgigantism → E22.0
  • Marie'sdisease or syndrome (acromegaly) → E22.0
  • Overproductiongrowth hormone → E22.0
  • Syndromecostovertebral → E22.0
  • SyndromeErdheim's → E22.0
  • SyndromeLaunois' → E22.0
  • SyndromeMarie's (acromegaly) → E22.0
  • Syndromepituitary → E22.0
  • SyndromeScaglietti-Dagnini → E22.0
  • Secretionantidiuretic hormone, inappropriate → E22.2
  • Syndromeinappropriate secretion of antidiuretic hormone → E22.2
  • SyndromeSchwartz-Bartter → E22.2
  • Hyperfunctionpituitary (gland) (anterior) → E22.9
  • Arthritis, arthritic (acute) (chronic) (nonpyogenic) (subacute)due to or associated withacromegaly → E22.0
  • Arthritis, arthritic (acute) (chronic) (nonpyogenic) (subacute)in (due to)acromegaly → E22.0
  • Arthropathyin (due to)acromegaly → E22.0 [M14.8-]
  • Hypersecretionhormone(s)growth → E22.0
  • Syndromecerebralgigantism → E22.0
  • Hypersecretionhormone(s)antidiuretic → E22.2
  • Inappropriatesecretionantidiuretic hormone (ADH) (excessive) → E22.2
  • Inappropriatesecretionpituitary (posterior) → E22.2
  • Secretionhormoneantidiuretic, inappropriate (syndrome) → E22.2
  • Hyperfunctionpituitary (gland) (anterior)specified NEC → E22.8
  • Precociouspubertycentral → E22.8
  • Puberty (development state)precocious (constitutional) (cryptogenic) (idiopathic)central → E22.8
  • Hypersecretionhormone(s)pituitary → E22.9
  • Increase, increasedfunctionpituitary (gland) (anterior) (lobe) → E22.9
  • Increase, increasedfunctionpituitary (gland) (anterior) (lobe)posterior → E22.2
  • Perversion, pervertedfunctionpituitary glandposterior lobe → E22.2
  • Puberty (development state)prematuredue topituitary (anterior) hyperfunction → E22.8

NCHS Alphabetic Index. Index first, then the Tabular List.

Hierarchy