DxCodebookFY2027 · Oct 1, 2026 – Sep 30, 2027

Category · FY2027

T45 Poisoning by, adverse effect of and underdosing of primarily systemic and hematological agents, not elsewhere classified

  • Header · not billable
  • Codes take a 7th character

T45 is not billable. The category heads 270 billable codes in FY2027, grouped under 11 subdivisions. Its codes take a 7th character, so none is complete with fewer than 7 characters.

Billable codes
270
Subdivisions
11
CC / MCC codes
0 / 0
HCC V28 codes
15
New FY2027
0
Index entries
0

Codes in T45

  1. T45.0
    Poisoning by, adverse effect of and underdosing of antiallergic and antiemetic drugs
    Header
    Excludes1 1

    Excludes1

    • poisoning by, adverse effect of and underdosing of phenothiazine-based neuroleptics (T43.3) T43.3
  2. T45.0X
    Poisoning by, adverse effect of and underdosing of antiallergic and antiemetic drugs
    Header
  3. T45.0X1
    Poisoning by antiallergic and antiemetic drugs, accidental (unintentional) +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
    Inclusion terms 1

    Inclusion terms

    • Poisoning by antiallergic and antiemetic drugs NOS
  4. T45.0X2
    Poisoning by antiallergic and antiemetic drugs, intentional self-harm +7th: A D S
    Needs 7th character155 (some 7th characters)Exempt: 2 of 3 7th characters
  5. T45.0X3
    Poisoning by antiallergic and antiemetic drugs, assault +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  6. T45.0X4
    Poisoning by antiallergic and antiemetic drugs, undetermined +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  7. T45.0X5
    Adverse effect of antiallergic and antiemetic drugs +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  8. T45.0X6
    Underdosing of antiallergic and antiemetic drugs +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  9. T45.1
    Poisoning by, adverse effect of and underdosing of antineoplastic and immunosuppressive drugs
    Header
    Excludes1 2

    Excludes1

    • poisoning by, adverse effect of and underdosing of immune checkpoint inhibitors and immunostimulant drugs (T45.A) T45.A
    • poisoning by, adverse effect of and underdosing of tamoxifen (T38.6) T38.6
  10. T45.1X
    Poisoning by, adverse effect of and underdosing of antineoplastic and immunosuppressive drugs
    Header
  11. T45.1X1
    Poisoning by antineoplastic and immunosuppressive drugs, accidental (unintentional) +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
    Inclusion terms 1

    Inclusion terms

    • Poisoning by antineoplastic and immunosuppressive drugs NOS
  12. T45.1X2
    Poisoning by antineoplastic and immunosuppressive drugs, intentional self-harm +7th: A D S
    Needs 7th character155 (some 7th characters)Exempt: 2 of 3 7th characters
  13. T45.1X3
    Poisoning by antineoplastic and immunosuppressive drugs, assault +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  14. T45.1X4
    Poisoning by antineoplastic and immunosuppressive drugs, undetermined +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  15. T45.1X5
    Adverse effect of antineoplastic and immunosuppressive drugs +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  16. T45.1X6
    Underdosing of antineoplastic and immunosuppressive drugs +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  17. T45.2
    Poisoning by, adverse effect of and underdosing of vitamins
    Header
    Excludes2 3

    Excludes2

    • poisoning by, adverse effect of and underdosing of nicotinic acid (derivatives) (T46.7) T46.7
    • poisoning by, adverse effect of and underdosing of iron (T45.4) T45.4
    • poisoning by, adverse effect of and underdosing of vitamin K (T45.7) T45.7
  18. T45.2X
    Poisoning by, adverse effect of and underdosing of vitamins
    Header
  19. T45.2X1
    Poisoning by vitamins, accidental (unintentional) +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
    Inclusion terms 1

    Inclusion terms

    • Poisoning by vitamins NOS
  20. T45.2X2
    Poisoning by vitamins, intentional self-harm +7th: A D S
    Needs 7th character155 (some 7th characters)Exempt: 2 of 3 7th characters
  21. T45.2X3
    Poisoning by vitamins, assault +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  22. T45.2X4
    Poisoning by vitamins, undetermined +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  23. T45.2X5
    Adverse effect of vitamins +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  24. T45.2X6
    Underdosing of vitamins +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
    Excludes1 1

    Excludes1

    • vitamin deficiencies (E50-E56) E50 E56
  25. T45.3
    Poisoning by, adverse effect of and underdosing of enzymes
    Header
  26. T45.3X
    Poisoning by, adverse effect of and underdosing of enzymes
    Header
  27. T45.3X1
    Poisoning by enzymes, accidental (unintentional) +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
    Inclusion terms 1

    Inclusion terms

    • Poisoning by enzymes NOS
  28. T45.3X2
    Poisoning by enzymes, intentional self-harm +7th: A D S
    Needs 7th character155 (some 7th characters)Exempt: 2 of 3 7th characters
  29. T45.3X3
    Poisoning by enzymes, assault +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  30. T45.3X4
    Poisoning by enzymes, undetermined +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  31. T45.3X5
    Adverse effect of enzymes +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  32. T45.3X6
    Underdosing of enzymes +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  33. T45.4
    Poisoning by, adverse effect of and underdosing of iron and its compounds
    Header
  34. T45.4X
    Poisoning by, adverse effect of and underdosing of iron and its compounds
    Header
  35. T45.4X1
    Poisoning by iron and its compounds, accidental (unintentional) +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
    Inclusion terms 1

    Inclusion terms

    • Poisoning by iron and its compounds NOS
  36. T45.4X2
    Poisoning by iron and its compounds, intentional self-harm +7th: A D S
    Needs 7th character155 (some 7th characters)Exempt: 2 of 3 7th characters
  37. T45.4X3
    Poisoning by iron and its compounds, assault +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  38. T45.4X4
    Poisoning by iron and its compounds, undetermined +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  39. T45.4X5
    Adverse effect of iron and its compounds +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  40. T45.4X6
    Underdosing of iron and its compounds +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
    Excludes1 1

    Excludes1

    • iron deficiency (E61.1) E61.1
  41. T45.5
    Poisoning by, adverse effect of and underdosing of anticoagulants and antithrombotic drugs
    Header
  42. T45.51
    Poisoning by, adverse effect of and underdosing of anticoagulants
    Header
  43. T45.511
    Poisoning by anticoagulants, accidental (unintentional) +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
    Inclusion terms 1

    Inclusion terms

    • Poisoning by anticoagulants NOS
  44. T45.512
    Poisoning by anticoagulants, intentional self-harm +7th: A D S
    Needs 7th character155 (some 7th characters)Exempt: 2 of 3 7th characters
  45. T45.513
    Poisoning by anticoagulants, assault +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  46. T45.514
    Poisoning by anticoagulants, undetermined +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  47. T45.515
    Adverse effect of anticoagulants +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  48. T45.516
    Underdosing of anticoagulants +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  49. T45.52
    Poisoning by, adverse effect of and underdosing of antithrombotic drugs
    Header
    Inclusion terms 1, Excludes2 2

    Inclusion terms

    • Poisoning by, adverse effect of and underdosing of antiplatelet drugs

    Excludes2

    • poisoning by, adverse effect of and underdosing of aspirin (T39.01-) T39.01
    • poisoning by, adverse effect of and underdosing of acetylsalicylic acid (T39.01-) T39.01
  50. T45.521
    Poisoning by antithrombotic drugs, accidental (unintentional) +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
    Inclusion terms 1

    Inclusion terms

    • Poisoning by antithrombotic drug NOS
  51. T45.522
    Poisoning by antithrombotic drugs, intentional self-harm +7th: A D S
    Needs 7th character155 (some 7th characters)Exempt: 2 of 3 7th characters
  52. T45.523
    Poisoning by antithrombotic drugs, assault +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  53. T45.524
    Poisoning by antithrombotic drugs, undetermined +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  54. T45.525
    Adverse effect of antithrombotic drugs +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  55. T45.526
    Underdosing of antithrombotic drugs +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  56. T45.6
    Poisoning by, adverse effect of and underdosing of fibrinolysis-affecting drugs
    Header
  57. T45.60
    Poisoning by, adverse effect of and underdosing of unspecified fibrinolysis-affecting drugs
    Header
  58. T45.601
    Poisoning by unspecified fibrinolysis-affecting drugs, accidental (unintentional) +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
    Inclusion terms 1

    Inclusion terms

    • Poisoning by fibrinolysis-affecting drug NOS
  59. T45.602
    Poisoning by unspecified fibrinolysis-affecting drugs, intentional self-harm +7th: A D S
    Needs 7th character155 (some 7th characters)Exempt: 2 of 3 7th characters
  60. T45.603
    Poisoning by unspecified fibrinolysis-affecting drugs, assault +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  61. T45.604
    Poisoning by unspecified fibrinolysis-affecting drugs, undetermined +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  62. T45.605
    Adverse effect of unspecified fibrinolysis-affecting drugs +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  63. T45.606
    Underdosing of unspecified fibrinolysis-affecting drugs +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  64. T45.61
    Poisoning by, adverse effect of and underdosing of thrombolytic drugs
    Header
  65. T45.611
    Poisoning by thrombolytic drug, accidental (unintentional) +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
    Inclusion terms 1

    Inclusion terms

    • Poisoning by thrombolytic drug NOS
  66. T45.612
    Poisoning by thrombolytic drug, intentional self-harm +7th: A D S
    Needs 7th character155 (some 7th characters)Exempt: 2 of 3 7th characters
  67. T45.613
    Poisoning by thrombolytic drug, assault +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  68. T45.614
    Poisoning by thrombolytic drug, undetermined +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  69. T45.615
    Adverse effect of thrombolytic drugs +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  70. T45.616
    Underdosing of thrombolytic drugs +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  71. T45.62
    Poisoning by, adverse effect of and underdosing of hemostatic drugs
    Header
  72. T45.621
    Poisoning by hemostatic drug, accidental (unintentional) +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
    Inclusion terms 1

    Inclusion terms

    • Poisoning by hemostatic drug NOS
  73. T45.622
    Poisoning by hemostatic drug, intentional self-harm +7th: A D S
    Needs 7th character155 (some 7th characters)Exempt: 2 of 3 7th characters
  74. T45.623
    Poisoning by hemostatic drug, assault +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  75. T45.624
    Poisoning by hemostatic drug, undetermined +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  76. T45.625
    Adverse effect of hemostatic drug +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  77. T45.626
    Underdosing of hemostatic drugs +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  78. T45.69
    Poisoning by, adverse effect of and underdosing of other fibrinolysis-affecting drugs
    Header
  79. T45.691
    Poisoning by other fibrinolysis-affecting drugs, accidental (unintentional) +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
    Inclusion terms 1

    Inclusion terms

    • Poisoning by other fibrinolysis-affecting drug NOS
  80. T45.692
    Poisoning by other fibrinolysis-affecting drugs, intentional self-harm +7th: A D S
    Needs 7th character155 (some 7th characters)Exempt: 2 of 3 7th characters
  81. T45.693
    Poisoning by other fibrinolysis-affecting drugs, assault +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  82. T45.694
    Poisoning by other fibrinolysis-affecting drugs, undetermined +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  83. T45.695
    Adverse effect of other fibrinolysis-affecting drugs +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  84. T45.696
    Underdosing of other fibrinolysis-affecting drugs +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  85. T45.7
    Poisoning by, adverse effect of and underdosing of anticoagulant antagonists, vitamin K and other coagulants
    Header
  86. T45.7X
    Poisoning by, adverse effect of and underdosing of anticoagulant antagonists, vitamin K and other coagulants
    Header
  87. T45.7X1
    Poisoning by anticoagulant antagonists, vitamin K and other coagulants, accidental (unintentional) +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
    Inclusion terms 1

    Inclusion terms

    • Poisoning by anticoagulant antagonists, vitamin K and other coagulants NOS
  88. T45.7X2
    Poisoning by anticoagulant antagonists, vitamin K and other coagulants, intentional self-harm +7th: A D S
    Needs 7th character155 (some 7th characters)Exempt: 2 of 3 7th characters
  89. T45.7X3
    Poisoning by anticoagulant antagonists, vitamin K and other coagulants, assault +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  90. T45.7X4
    Poisoning by anticoagulant antagonists, vitamin K and other coagulants, undetermined +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  91. T45.7X5
    Adverse effect of anticoagulant antagonists, vitamin K and other coagulants +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  92. T45.7X6
    Underdosing of anticoagulant antagonist, vitamin K and other coagulants +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
    Excludes1 1

    Excludes1

    • vitamin K deficiency (E56.1) E56.1
  93. T45.8
    Poisoning by, adverse effect of and underdosing of other primarily systemic and hematological agents
    Header
    Inclusion terms 3, Excludes2 3

    Inclusion terms

    • Poisoning by, adverse effect of and underdosing of liver preparations and other antianemic agents
    • Poisoning by, adverse effect of and underdosing of natural blood and blood products
    • Poisoning by, adverse effect of and underdosing of plasma substitute

    Excludes2

    • poisoning by, adverse effect of and underdosing of immunoglobulin (T50.Z1) T50.Z1
    • poisoning by, adverse effect of and underdosing of iron (T45.4) T45.4
    • transfusion reactions (T80.-) T80
  94. T45.8X
    Poisoning by, adverse effect of and underdosing of other primarily systemic and hematological agents
    Header
  95. T45.8X1
    Poisoning by other primarily systemic and hematological agents, accidental (unintentional) +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
    Inclusion terms 1

    Inclusion terms

    • Poisoning by other primarily systemic and hematological agents NOS
  96. T45.8X2
    Poisoning by other primarily systemic and hematological agents, intentional self-harm +7th: A D S
    Needs 7th character155 (some 7th characters)Exempt: 2 of 3 7th characters
  97. T45.8X3
    Poisoning by other primarily systemic and hematological agents, assault +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  98. T45.8X4
    Poisoning by other primarily systemic and hematological agents, undetermined +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  99. T45.8X5
    Adverse effect of other primarily systemic and hematological agents +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  100. T45.8X6
    Underdosing of other primarily systemic and hematological agents +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  101. T45.9
    Poisoning by, adverse effect of and underdosing of unspecified primarily systemic and hematological agent
    Header
  102. T45.91
    Poisoning by unspecified primarily systemic and hematological agent, accidental (unintentional) +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
    Inclusion terms 1

    Inclusion terms

    • Poisoning by primarily systemic and hematological agent NOS
  103. T45.92
    Poisoning by unspecified primarily systemic and hematological agent, intentional self-harm +7th: A D S
    Needs 7th character155 (some 7th characters)Exempt: 2 of 3 7th characters
  104. T45.93
    Poisoning by unspecified primarily systemic and hematological agent, assault +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  105. T45.94
    Poisoning by unspecified primarily systemic and hematological agent, undetermined +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  106. T45.95
    Adverse effect of unspecified primarily systemic and hematological agent +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  107. T45.96
    Underdosing of unspecified primarily systemic and hematological agent +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  108. T45.A
    Poisoning by, adverse effect of and underdosing of immune checkpoint inhibitors and immunostimulant drugs
    Header
    Excludes1 1

    Excludes1

    • poisoning by, adverse effect of and underdosing of antineoplastic and immunosuppressive drug (T45.1) T45.1
  109. T45.AX
    Poisoning by, adverse effect of and underdosing of immune checkpoint inhibitors and immunostimulant drugs
    Header
  110. T45.AX1
    Poisoning by immune checkpoint inhibitors and immunostimulant drugs, accidental (unintentional) +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
    Inclusion terms 1

    Inclusion terms

    • Poisoning by immune checkpoint inhibitors and immunostimulant drugs NOS
  111. T45.AX2
    Poisoning by immune checkpoint inhibitors and immunostimulant drugs, intentional self-harm +7th: A D S
    Needs 7th character155 (some 7th characters)Exempt: 2 of 3 7th characters
  112. T45.AX3
    Poisoning by immune checkpoint inhibitors and immunostimulant drugs, assault +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  113. T45.AX4
    Poisoning by immune checkpoint inhibitors and immunostimulant drugs, undetermined +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  114. T45.AX5
    Adverse effect of immune checkpoint inhibitors and immunostimulant drugs +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  115. T45.AX6
    Underdosing of immune checkpoint inhibitors and immunostimulant drugs +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters

Sources of each column. Rows marked +7th need a 7th character: pick one to build the full code; its code card has its own flags.

Instructions

Notes that also apply

Block T36-T50 instructions (Notes 1, Includes 4, Excludes1 1, Excludes2 5, Code first 7, Use additional code 4): printed on the block page.

Chapter 19 instructions (Notes 2, Excludes2 2, Use additional code 1): printed on the chapter 19 page.

7th characters

7th characters for T45 defined here

The appropriate 7th character is to be added to each code from category T45

7th characters for T45
7thMeaning (NCHS)
Ainitial encounter
Dsubsequent encounter
Ssequela

A code that takes a 7th character is invalid without it; the placeholder X fills a code shorter than 6 characters (Official Guidelines I.A.5). How 7th characters work.

Hierarchy