DxCodebookFY2027 · Oct 1, 2026 – Sep 30, 2027

Category · FY2027

T80 Complications following infusion, transfusion and therapeutic injection

  • Header · not billable
  • Codes take a 7th character

T80 is not billable. The category heads 114 billable codes in FY2027, grouped under 10 subdivisions. Its codes take a 7th character, so none is complete with fewer than 7 characters.

Index → code

Billable codes
114
Subdivisions
10
CC / MCC codes
33 / 1
HCC V28 codes
0
New FY2027
0
Index entries
146

Codes in T80

  1. T80.0
    Air embolism following infusion, transfusion and therapeutic injection +7th: A D S
    Needs 7th characterMCC AExempt: 2 of 3 7th characters
  2. T80.1
    Vascular complications following infusion, transfusion and therapeutic injection +7th: A D S
    Needs 7th characterCC AExempt: 2 of 3 7th characters
    Excludes2 4, Use additional code 1

    Excludes2

    • extravasation of vesicant agent (T80.81-) T80.81
    • infiltration of vesicant agent (T80.81-) T80.81
    • vascular complications specified as due to prosthetic devices, implants and grafts (T82.8-, T83.8-, T84.8-, T85.8-) T82.8 T83.8 T84.8 T85.8
    • postprocedural vascular complications (T81.7-) T81.7

    Use additional code

    • code to identify the vascular complication
  3. T80.2
    Infections following infusion, transfusion and therapeutic injection
    Header
    Excludes2 2, Use additional code 3

    Excludes2

    Use additional code

    • code to identify the specific infection, such as:
    • sepsis (A41.9) A41.9
    • code (R65.2-) to identify severe sepsis, if applicable R65.2
  4. T80.21
    Infection due to central venous catheter
    Header
    Inclusion terms 1

    Inclusion terms

    • Infection due to pulmonary artery catheter (Swan-Ganz catheter)
  5. T80.211
    Bloodstream infection due to central venous catheter +7th: A D S
    Needs 7th characterCC AExempt: 2 of 3 7th characters
    Inclusion terms 8

    Inclusion terms

    • Catheter-related bloodstream infection (CRBSI) NOS
    • Central line-associated bloodstream infection (CLABSI)
    • Bloodstream infection due to Hickman catheter
    • Bloodstream infection due to peripherally inserted central catheter (PICC)
    • Bloodstream infection due to portacath (port-a-cath)
    • Bloodstream infection due to pulmonary artery catheter
    • Bloodstream infection due to triple lumen catheter
    • Bloodstream infection due to umbilical venous catheter
  6. T80.212
    Local infection due to central venous catheter +7th: A D S
    Needs 7th characterCC AExempt: 2 of 3 7th characters
    Inclusion terms 9

    Inclusion terms

    • Exit or insertion site infection
    • Local infection due to Hickman catheter
    • Local infection due to peripherally inserted central catheter (PICC)
    • Local infection due to portacath (port-a-cath)
    • Local infection due to pulmonary artery catheter
    • Local infection due to triple lumen catheter
    • Local infection due to umbilical venous catheter
    • Port or reservoir infection
    • Tunnel infection
  7. T80.218
    Other infection due to central venous catheter +7th: A D S
    Needs 7th characterCC AExempt: 2 of 3 7th characters
    Inclusion terms 7

    Inclusion terms

    • Other central line-associated infection
    • Other infection due to Hickman catheter
    • Other infection due to peripherally inserted central catheter (PICC)
    • Other infection due to portacath (port-a-cath)
    • Other infection due to pulmonary artery catheter
    • Other infection due to triple lumen catheter
    • Other infection due to umbilical venous catheter
  8. T80.219
    Unspecified infection due to central venous catheter +7th: A D S
    Needs 7th characterCC AExempt: 2 of 3 7th characters
    Inclusion terms 7

    Inclusion terms

    • Central line-associated infection NOS
    • Unspecified infection due to Hickman catheter
    • Unspecified infection due to peripherally inserted central catheter (PICC)
    • Unspecified infection due to portacath (port-a-cath)
    • Unspecified infection due to pulmonary artery catheter
    • Unspecified infection due to triple lumen catheter
    • Unspecified infection due to umbilical venous catheter
  9. T80.22
    Acute infection following transfusion, infusion, or injection of blood and blood products +7th: A D S
    Needs 7th characterCC AExempt: 2 of 3 7th characters
  10. T80.29
    Infection following other infusion, transfusion and therapeutic injection +7th: A D S
    Needs 7th characterCC AExempt: 2 of 3 7th characters
  11. T80.3
    ABO incompatibility reaction due to transfusion of blood or blood products
    Header
    Excludes1 1

    Excludes1

    • minor blood group antigens reactions (Duffy) (E) (K) (Kell) (Kidd) (Lewis) (M) (N) (P) (S) (T80.A-) T80.A
  12. T80.30
    ABO incompatibility reaction due to transfusion of blood or blood products, unspecified +7th: A D S
    Needs 7th characterCC AExempt: 2 of 3 7th characters
    Inclusion terms 2

    Inclusion terms

    • ABO incompatibility blood transfusion NOS
    • Reaction to ABO incompatibility from transfusion NOS
  13. T80.31
    ABO incompatibility with hemolytic transfusion reaction
    Header
  14. T80.310
    ABO incompatibility with acute hemolytic transfusion reaction +7th: A D S
    Needs 7th characterCC AExempt: 2 of 3 7th characters
    Inclusion terms 2

    Inclusion terms

    • ABO incompatibility with hemolytic transfusion reaction less than 24 hours after transfusion
    • Acute hemolytic transfusion reaction (AHTR) due to ABO incompatibility
  15. T80.311
    ABO incompatibility with delayed hemolytic transfusion reaction +7th: A D S
    Needs 7th characterCC AExempt: 2 of 3 7th characters
    Inclusion terms 2

    Inclusion terms

    • ABO incompatibility with hemolytic transfusion reaction 24 hours or more after transfusion
    • Delayed hemolytic transfusion reaction (DHTR) due to ABO incompatibility
  16. T80.319
    ABO incompatibility with hemolytic transfusion reaction, unspecified +7th: A D S
    Needs 7th characterCC AExempt: 2 of 3 7th characters
    Inclusion terms 2

    Inclusion terms

    • ABO incompatibility with hemolytic transfusion reaction at unspecified time after transfusion
    • Hemolytic transfusion reaction (HTR) due to ABO incompatibility NOS
  17. T80.39
    Other ABO incompatibility reaction due to transfusion of blood or blood products +7th: A D S
    Needs 7th characterCC AExempt: 2 of 3 7th characters
    Inclusion terms 3

    Inclusion terms

    • Delayed serologic transfusion reaction (DSTR) from ABO incompatibility
    • Other ABO incompatible blood transfusion
    • Other reaction to ABO incompatible blood transfusion
  18. T80.4
    Rh incompatibility reaction due to transfusion of blood or blood products
    Header
    Inclusion terms 1

    Inclusion terms

    • Reaction due to incompatibility of Rh antigens (C) (c) (D) (E) (e)
  19. T80.40
    Rh incompatibility reaction due to transfusion of blood or blood products, unspecified +7th: A D S
    Needs 7th characterCC AExempt: 2 of 3 7th characters
    Inclusion terms 2

    Inclusion terms

    • Reaction due to Rh factor in transfusion NOS
    • Rh incompatible blood transfusion NOS
  20. T80.41
    Rh incompatibility with hemolytic transfusion reaction
    Header
  21. T80.410
    Rh incompatibility with acute hemolytic transfusion reaction +7th: A D S
    Needs 7th characterCC AExempt: 2 of 3 7th characters
    Inclusion terms 2

    Inclusion terms

    • Acute hemolytic transfusion reaction (AHTR) due to Rh incompatibility
    • Rh incompatibility with hemolytic transfusion reaction less than 24 hours after transfusion
  22. T80.411
    Rh incompatibility with delayed hemolytic transfusion reaction +7th: A D S
    Needs 7th characterCC AExempt: 2 of 3 7th characters
    Inclusion terms 2

    Inclusion terms

    • Delayed hemolytic transfusion reaction (DHTR) due to Rh incompatibility
    • Rh incompatibility with hemolytic transfusion reaction 24 hours or more after transfusion
  23. T80.419
    Rh incompatibility with hemolytic transfusion reaction, unspecified +7th: A D S
    Needs 7th characterCC AExempt: 2 of 3 7th characters
    Inclusion terms 2

    Inclusion terms

    • Rh incompatibility with hemolytic transfusion reaction at unspecified time after transfusion
    • Hemolytic transfusion reaction (HTR) due to Rh incompatibility NOS
  24. T80.49
    Other Rh incompatibility reaction due to transfusion of blood or blood products +7th: A D S
    Needs 7th characterCC AExempt: 2 of 3 7th characters
    Inclusion terms 2

    Inclusion terms

    • Delayed serologic transfusion reaction (DSTR) from Rh incompatibility
    • Other reaction to Rh incompatible blood transfusion
  25. T80.A
    Non-ABO incompatibility reaction due to transfusion of blood or blood products
    Header
    Inclusion terms 1

    Inclusion terms

    • Reaction due to incompatibility of minor antigens (Duffy) (Kell) (Kidd) (Lewis) (M) (N) (P) (S)
  26. T80.A0
    Non-ABO incompatibility reaction due to transfusion of blood or blood products, unspecified +7th: A D S
    Needs 7th characterCC AExempt: 2 of 3 7th characters
    Inclusion terms 1

    Inclusion terms

    • Non-ABO antigen incompatibility reaction from transfusion NOS
  27. T80.A1
    Non-ABO incompatibility with hemolytic transfusion reaction
    Header
  28. T80.A10
    Non-ABO incompatibility with acute hemolytic transfusion reaction +7th: A D S
    Needs 7th characterCC AExempt: 2 of 3 7th characters
    Inclusion terms 2

    Inclusion terms

    • Acute hemolytic transfusion reaction (AHTR) due to non-ABO incompatibility
    • Non-ABO incompatibility with hemolytic transfusion reaction less than 24 hours after transfusion
  29. T80.A11
    Non-ABO incompatibility with delayed hemolytic transfusion reaction +7th: A D S
    Needs 7th characterCC AExempt: 2 of 3 7th characters
    Inclusion terms 2

    Inclusion terms

    • Delayed hemolytic transfusion reaction (DHTR) due to non-ABO incompatibility
    • Non-ABO incompatibility with hemolytic transfusion reaction 24 or more hours after transfusion
  30. T80.A19
    Non-ABO incompatibility with hemolytic transfusion reaction, unspecified +7th: A D S
    Needs 7th characterCC AExempt: 2 of 3 7th characters
    Inclusion terms 2

    Inclusion terms

    • Hemolytic transfusion reaction (HTR) due to non-ABO incompatibility NOS
    • Non-ABO incompatibility with hemolytic transfusion reaction at unspecified time after transfusion
  31. T80.A9
    Other non-ABO incompatibility reaction due to transfusion of blood or blood products +7th: A D S
    Needs 7th characterCC AExempt: 2 of 3 7th characters
    Inclusion terms 2

    Inclusion terms

    • Delayed serologic transfusion reaction (DSTR) from non-ABO incompatibility
    • Other reaction to non-ABO incompatible blood transfusion
  32. T80.5
    Anaphylactic reaction due to serum
    Header
    Inclusion terms 4, Excludes1 5

    Inclusion terms

    • Allergic shock due to serum
    • Anaphylactic shock due to serum
    • Anaphylactoid reaction due to serum
    • Anaphylaxis due to serum

    Excludes1

    • ABO incompatibility reaction due to transfusion of blood or blood products (T80.3-) T80.3
    • allergic reaction or shock NOS (T78.2) T78.2
    • anaphylactic reaction or shock NOS (T78.2) T78.2
    • anaphylactic reaction or shock due to adverse effect of correct medicinal substance properly administered (T88.6) T88.6
    • other serum reaction (T80.6-) T80.6
  33. T80.51
    Anaphylactic reaction due to administration of blood and blood products +7th: A D S
    Needs 7th characterCC AExempt: 2 of 3 7th characters
  34. T80.52
    Anaphylactic reaction due to vaccination +7th: A D S
    Needs 7th characterCC AExempt: 2 of 3 7th characters
  35. T80.59
    Anaphylactic reaction due to other serum +7th: A D S
    Needs 7th characterCC AExempt: 2 of 3 7th characters
  36. T80.6
    Other serum reactions
    Header
    Inclusion terms 5, Excludes2 1

    Inclusion terms

    • Intoxication by serum
    • Protein sickness
    • Serum rash
    • Serum sickness
    • Serum urticaria

    Excludes2

    • serum hepatitis (B16-B19) B16 B19
  37. T80.61
    Other serum reaction due to administration of blood and blood products +7th: A D S
    Needs 7th characterCC AExempt: 2 of 3 7th characters
  38. T80.62
    Other serum reaction due to vaccination +7th: A D S
    Needs 7th characterCC AExempt: 2 of 3 7th characters
  39. T80.69
    Other serum reaction due to other serum +7th: A D S
    Needs 7th characterCC AExempt: 2 of 3 7th characters
    Code also 1

    Code also

    • , if applicable, arthropathy in hypersensitivity reactions classified elsewhere (M36.4) M36.4
  40. T80.8
    Other complications following infusion, transfusion and therapeutic injection
    Header
  41. T80.81
    Extravasation of vesicant agent
    Header
    Inclusion terms 1

    Inclusion terms

    • Infiltration of vesicant agent
  42. T80.810
    Extravasation of vesicant antineoplastic chemotherapy +7th: A D S
    Needs 7th characterCC AExempt: 2 of 3 7th characters
    Inclusion terms 1

    Inclusion terms

    • Infiltration of vesicant antineoplastic chemotherapy
  43. T80.818
    Extravasation of other vesicant agent +7th: A D S
    Needs 7th characterCC AExempt: 2 of 3 7th characters
    Inclusion terms 1

    Inclusion terms

    • Infiltration of other vesicant agent
  44. T80.82
    Complication of immune effector cellular therapy +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
    Inclusion terms 2, Excludes2 3, Use additional code 3

    Inclusion terms

    • Complication of chimeric antigen receptor (CAR-T) cell therapy
    • Complication of IEC therapy

    Excludes2

    • adverse effect of immune checkpoint inhibitors and immunostimulant drugs (T45.AX5) T45.AX5
    • complication of bone marrow transplant (T86.0) T86.0
    • complication of stem cell transplant (T86.5) T86.5

    Use additional code

    • code to identify the specific complication, such as:
    • cytokine release syndrome (D89.83-) D89.83
    • immune effector cell-associated neurotoxicity syndrome (G92.0-) G92.0
  45. T80.89
    Other complications following infusion, transfusion and therapeutic injection +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
    Inclusion terms 1, Use additional code 1

    Inclusion terms

    • Delayed serologic transfusion reaction (DSTR), unspecified incompatibility

    Use additional code

    • code to identify graft-versus-host reaction, if applicable, (D89.81-) D89.81
  46. T80.9
    Unspecified complication following infusion, transfusion and therapeutic injection
    Header
  47. T80.90
    Unspecified complication following infusion and therapeutic injection +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
  48. T80.91
    Hemolytic transfusion reaction, unspecified incompatibility
    Header
    Excludes1 3

    Excludes1

    • ABO incompatibility with hemolytic transfusion reaction (T80.31-) T80.31
    • Non-ABO incompatibility with hemolytic transfusion reaction (T80.A1-) T80.A1
    • Rh incompatibility with hemolytic transfusion reaction (T80.41-) T80.41
  49. T80.910
    Acute hemolytic transfusion reaction, unspecified incompatibility +7th: A D S
    Needs 7th characterCC AExempt: 2 of 3 7th characters
  50. T80.911
    Delayed hemolytic transfusion reaction, unspecified incompatibility +7th: A D S
    Needs 7th characterCC AExempt: 2 of 3 7th characters
  51. T80.919
    Hemolytic transfusion reaction, unspecified incompatibility, unspecified as acute or delayed +7th: A D S
    Needs 7th characterCC AExempt: 2 of 3 7th characters
    Inclusion terms 1

    Inclusion terms

    • Hemolytic transfusion reaction NOS
  52. T80.92
    Unspecified transfusion reaction +7th: A D S
    Needs 7th characterExempt: 2 of 3 7th characters
    Inclusion terms 1

    Inclusion terms

    • Transfusion reaction NOS

CC/MCC: as a secondary diagnosis, unless the principal diagnosis is on the code’s PDX exclusion list (MS-DRG v44 Appendix C; list on the code card).

Sources of each column. Rows marked +7th need a 7th character: pick one to build the full code; its code card has its own flags.

Instructions

At T80

Includes

  • complications following perfusion

Excludes2

  • bone marrow transplant rejection (T86.01) T86.01
  • febrile nonhemolytic transfusion reaction (R50.84) R50.84
  • fluid overload due to transfusion (E87.71) E87.71
  • posttransfusion purpura (D69.51) D69.51
  • transfusion associated circulatory overload (TACO) (E87.71) E87.71
  • transfusion (red blood cell) associated hemochromatosis (E83.111) E83.111
  • transfusion related acute lung injury (TRALI) (J95.84) J95.84

Notes that also apply

Block T80-T88 instructions (Excludes2 21, Use additional code 3): printed on the block page.

Chapter 19 instructions (Notes 2, Excludes2 2, Use additional code 1): printed on the chapter 19 page.

7th characters

7th characters for T80 defined here

The appropriate 7th character is to be added to each code from category T80

7th characters for T80
7thMeaning (NCHS)
Ainitial encounter
Dsubsequent encounter
Ssequela

A code that takes a 7th character is invalid without it; the placeholder X fills a code shorter than 6 characters (Official Guidelines I.A.5). How 7th characters work.

Index entries

  • Infection, infected, infective (opportunistic)catheter-related bloodstream (CRBSI) → T80.211
  • Infection, infected, infective (opportunistic)port or reservoir → T80.212
  • Infection, infected, infective (opportunistic)tunnel → T80.212
  • Infection, infected, infective (opportunistic)central line-associated → T80.219
  • Allergy, allergic (reaction) (to)serum → T80.69
  • Disease, diseasedserum NEC → T80.69
  • Effect, adverseserum NEC → T80.69
  • Intoxicationserum → T80.69
  • Neuritis (rheumatoid)serum → T80.69
  • Proteinsickness → T80.69
  • Rash (toxic)serum → T80.69
  • Reactionserum → T80.69
  • Serumallergy, allergic reaction → T80.69
  • Serumarthritis → T80.69
  • Serumcomplication or reaction NEC → T80.69
  • Serumdisease NEC → T80.69
  • Serumintoxication → T80.69
  • Serumneuritis → T80.69
  • Serumpoisoning NEC → T80.69
  • Serumrash NEC → T80.69
  • Serumreaction NEC → T80.69
  • Serumsickness NEC → T80.69
  • Serumurticaria → T80.69
  • Sicknessprotein → T80.69
  • Sicknessserum NEC → T80.69
  • Urticariaserum → T80.69
  • Complication(s) (from) (of)chimeric antigen receptor (CAR-T) cell therapy → T80.82
  • Complication(s) (from) (of)IEC (immune effector cellular) therapy → T80.82
  • Complication(s) (from) (of)immune effector cellular (IEC) therapy → T80.82
  • Hemoglobinemiadue to blood transfusion → T80.89
  • Hemosiderosis (dietary)transfusion → T80.89
  • Complication(s) (from) (of)extracorporeal circulation → T80.90
  • Complication(s) (from) (of)infusion (procedure) → T80.90
  • Complication(s) (from) (of)injection (procedure) → T80.90
  • Complication(s) (from) (of)perfusion NEC → T80.90
  • Complication(s) (from) (of)transfusion (blood) (lymphocytes) (plasma) → T80.92
  • Complication(s) (from) (of)infusion (procedure)air embolism → T80.0
  • Complication(s) (from) (of)transfusion (blood) (lymphocytes) (plasma)air embolism → T80.0
  • Complication(s) (from) (of)vascularfollowing infusion, therapeutic injection or transfusion → T80.1
  • Infection, infected, infective (opportunistic)central line-associatedbloodstream (CLABSI) → T80.211

106 more, longer entries are not listed; the search box finds them by word.

NCHS Alphabetic Index. Index first, then the Tabular List.

Hierarchy