DxCodebookFY2027 · Oct 1, 2026 – Sep 30, 2027

Category · FY2027

D80 Immunodeficiency with predominantly antibody defects

  • Header · not billable

D80 is not billable. The category heads 10 billable codes in FY2027: the 10 codes directly below it.

Index → code

  • Hypogammaglobulinemia → D80.1
  • Bruton's X-linked agammaglobulinemia → D80.0
  • Agammaglobulinemia (acquired (secondary)) (nonfamilial) → D80.1

Where it sits

  1. Chapter 3 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
  2. D80-D89 Certain disorders involving the immune mechanism (D80-D89)
  3. D80 Immunodeficiency with predominantly antibody defects
Billable codes
10
Subdivisions
10
CC / MCC codes
10 / 0
HCC V28 codes
5
New FY2027
0
Index entries
52

Codes in D80

  1. D80.0
    Hereditary hypogammaglobulinemia
    BillableCC115
    Inclusion terms 2

    Inclusion terms

    • Autosomal recessive agammaglobulinemia (Swiss type)
    • X-linked agammaglobulinemia [Bruton] (with growth hormone deficiency)
  2. D80.1
    Nonfamilial hypogammaglobulinemia
    BillableCC
    Inclusion terms 3

    Inclusion terms

    • Agammaglobulinemia with immunoglobulin-bearing B-lymphocytes
    • Common variable agammaglobulinemia [CVAgamma]
    • Hypogammaglobulinemia NOS
  3. D80.2
    Selective deficiency of immunoglobulin A [IgA]
    BillableCC115
  4. D80.3
    Selective deficiency of immunoglobulin G [IgG] subclasses
    BillableCC115
  5. D80.4
    Selective deficiency of immunoglobulin M [IgM]
    BillableCC115
  6. D80.5
    Immunodeficiency with increased immunoglobulin M [IgM]
    BillableCC115
  7. D80.6
    Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia
    BillableCC
  8. D80.7
    Transient hypogammaglobulinemia of infancy
    BillableCC
  9. D80.8
    Other immunodeficiencies with predominantly antibody defects
    BillableCC
    Inclusion terms 1

    Inclusion terms

    • Kappa light chain deficiency
  10. D80.9
    Immunodeficiency with predominantly antibody defects, unspecified
    BillableCC

CC/MCC: as a secondary diagnosis, unless the principal diagnosis is on the code’s PDX exclusion list (MS-DRG v44 Appendix C; list on the code card).

Sources of each column.

Instructions

Notes that also apply

Block D80-D89 instructions (Includes 3, Excludes1 2, Excludes2 1): printed on the block page.

Chapter 3 instructions (Excludes2 9): printed on the chapter 3 page.

Index entries

  • Bruton's X-linked agammaglobulinemia → D80.0
  • Agammaglobulinemia (acquired (secondary)) (nonfamilial) → D80.1
  • Hypogammaglobulinemia → D80.1
  • Agammaglobulinemia (acquired (secondary)) (nonfamilial)autosomal recessive (Swiss type) → D80.0
  • Agammaglobulinemia (acquired (secondary)) (nonfamilial)Bruton's X-linked → D80.0
  • Agammaglobulinemia (acquired (secondary)) (nonfamilial)congenital sex-linked → D80.0
  • Agammaglobulinemia (acquired (secondary)) (nonfamilial)hereditary → D80.0
  • Agammaglobulinemia (acquired (secondary)) (nonfamilial)Swiss type (autosomal recessive) → D80.0
  • Agammaglobulinemia (acquired (secondary)) (nonfamilial)X-linked (with growth hormone deficiency) (Bruton) → D80.0
  • Hypogammaglobulinemiahereditary → D80.0
  • Immunodeficiencyautosomal recessive, Swiss type → D80.0
  • Absence (of) (organ or part) (complete or partial)gamma globulin in blood → D80.1
  • Agammaglobulinemia (acquired (secondary)) (nonfamilial)common variable (CVAgamma) → D80.1
  • Deficiency, deficientgammaglobulin in blood → D80.1
  • Hypogammaglobulinemianonfamilial → D80.1
  • Absence (of) (organ or part) (complete or partial)immunoglobulin, isolated NEC → D80.3
  • ImmunodeficiencyX-linked, with increased IgM → D80.5
  • Hypogammaglobulinemiatransient, of infancy → D80.7
  • Deficiency, deficientkappa-light chain → D80.8
  • Defect, defectiveantibody immunodeficiency → D80.9
  • Syndromeantibody deficiency → D80.9
  • Absence (of) (organ or part) (complete or partial)gamma globulin in bloodhereditary → D80.0
  • Deficiency, deficientgammaglobulin in bloodhereditary → D80.0
  • Syndromeantibody deficiencycongenital → D80.0
  • Agammaglobulinemia (acquired (secondary)) (nonfamilial)withimmunoglobulin-bearing B-lymphocytes → D80.1
  • Arthritis, arthritic (acute) (chronic) (nonpyogenic) (subacute)in (due to)hypogammaglobulinemia → D80.1
  • Syndromeantibody deficiencyagammaglobulinemic → D80.1
  • Syndromeantibody deficiencyhypogammaglobulinemic → D80.1
  • Absence (of) (organ or part) (complete or partial)immunoglobulin, isolated NECIgA → D80.2
  • Deficiency, deficientimmunityIgA (secretory) → D80.2
  • Deficiency, deficientimmunoglobulin, selectiveA (IgA) → D80.2
  • Immunodeficiencyselective, immunoglobulinA (IgA) → D80.2
  • Absence (of) (organ or part) (complete or partial)immunoglobulin, isolated NECIgG → D80.3
  • Deficiency, deficientimmunityIgG → D80.3
  • Deficiency, deficientimmunoglobulin, selectiveG (IgG) (subclasses) → D80.3
  • Immunodeficiencyselective, immunoglobulinG (IgG) (subclasses) → D80.3
  • Absence (of) (organ or part) (complete or partial)immunoglobulin, isolated NECIgM → D80.4
  • Deficiency, deficientimmunityIgM → D80.4
  • Deficiency, deficientimmunoglobulin, selectiveM (IgM) → D80.4
  • Immunodeficiencyselective, immunoglobulinM (IgM) → D80.4

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