DxCodebookFY2027 · Oct 1, 2026 – Sep 30, 2027

Category · FY2027

Z16 Resistance to antimicrobial drugs

  • Header · not billable

Z16 is not billable. The category heads 19 billable codes in FY2027, grouped under 3 subdivisions.

Index → code

  • Drugresistant organism infection → Z16.30
  • Resistance, resistant (to)organism(s)todrug → Z16.30
  • Resistance, resistant (to)organism(s)todrugantiviral → Z16.33

Where it sits

  1. Chapter 21 Factors influencing health status and contact with health services (Z00-Z99)
  2. Z16 Resistance to antimicrobial drugs (Z16)
  3. Z16 Resistance to antimicrobial drugs
Billable codes
19
Subdivisions
3
CC / MCC codes
19 / 0
HCC V28 codes
0
New FY2027
0
Index entries
35

Codes in Z16

  1. Z16.1
    Resistance to beta lactam antibiotics
    Header
  2. Z16.10
    Resistance to unspecified beta lactam antibiotics
    BillableCC
  3. Z16.11
    Resistance to penicillins
    BillableCC
    Inclusion terms 2

    Inclusion terms

    • Resistance to amoxicillin
    • Resistance to ampicillin
  4. Z16.12
    Extended spectrum beta lactamase (ESBL) resistance
    BillableCC
    Excludes2 1

    Excludes2

    • Methicillin resistant Staphylococcus aureus infection in diseases classified elsewhere (B95.62) B95.62
  5. Z16.13
    Resistance to carbapenem
    BillableCC
  6. Z16.19
    Resistance to other specified beta lactam antibiotics
    BillableCC
    Inclusion terms 1

    Inclusion terms

    • Resistance to cephalosporins
  7. Z16.2
    Resistance to other antibiotics
    Header
  8. Z16.20
    Resistance to unspecified antibiotic
    BillableCC
    Inclusion terms 1

    Inclusion terms

    • Resistance to antibiotics NOS
  9. Z16.21
    Resistance to vancomycin
    BillableCC
  10. Z16.22
    Resistance to vancomycin related antibiotics
    BillableCC
  11. Z16.23
    Resistance to quinolones and fluoroquinolones
    BillableCC
  12. Z16.24
    Resistance to multiple antibiotics
    BillableCC
  13. Z16.29
    Resistance to other single specified antibiotic
    BillableCC
    Inclusion terms 4

    Inclusion terms

    • Resistance to aminoglycosides
    • Resistance to macrolides
    • Resistance to sulfonamides
    • Resistance to tetracyclines
  14. Z16.3
    Resistance to other antimicrobial drugs
    Header
    Excludes1 1

    Excludes1

    • resistance to antibiotics (Z16.1-, Z16.2-) Z16.1 Z16.2
  15. Z16.30
    Resistance to unspecified antimicrobial drugs
    BillableCC
    Inclusion terms 1

    Inclusion terms

    • Drug resistance NOS
  16. Z16.31
    Resistance to antiparasitic drug(s)
    BillableCC
    Inclusion terms 1

    Inclusion terms

    • Resistance to quinine and related compounds
  17. Z16.32
    Resistance to antifungal drug(s)
    BillableCC
  18. Z16.33
    Resistance to antiviral drug(s)
    BillableCC
  19. Z16.34
    Resistance to antimycobacterial drug(s)
    Header
    Inclusion terms 1

    Inclusion terms

    • Resistance to tuberculostatics
  20. Z16.341
    Resistance to single antimycobacterial drug
    BillableCC
    Inclusion terms 1

    Inclusion terms

    • Resistance to antimycobacterial drug NOS
  21. Z16.342
    Resistance to multiple antimycobacterial drugs
    BillableCC
  22. Z16.35
    Resistance to multiple antimicrobial drugs
    BillableCC
    Excludes1 1

    Excludes1

    • Resistance to multiple antibiotics only (Z16.24) Z16.24
  23. Z16.39
    Resistance to other specified antimicrobial drug
    BillableCC

CC/MCC: as a secondary diagnosis, unless the principal diagnosis is on the code’s PDX exclusion list (MS-DRG v44 Appendix C; list on the code card).

Sources of each column.

Instructions

At Z16

Notes

  • The codes in this category are provided for use as additional codes to identify the resistance and non-responsiveness of a condition to antimicrobial drugs.

Excludes1

  • Methicillin resistant Staphylococcus aureus infection (A49.02) A49.02
  • Methicillin resistant Staphylococcus aureus pneumonia (J15.212) J15.212
  • Sepsis due to Methicillin resistant Staphylococcus aureus (A41.02) A41.02

Code first

  • the infection

Notes that also apply

Chapter 21 instructions (Notes 3): printed on the chapter 21 page.

Index entries

  • Drugresistant organism infection → Z16.30
  • Resistance, resistant (to)organism(s)todrug → Z16.30
  • Resistance, resistant (to)organism(s)todrugbeta lactam antibiotics → Z16.10
  • Resistance, resistant (to)organism(s)todrugamoxicillin → Z16.11
  • Resistance, resistant (to)organism(s)todrugampicillin → Z16.11
  • Resistance, resistant (to)organism(s)todrugpenicillins → Z16.11
  • Resistance, resistant (to)organism(s)todrugextended beta lactamase (ESBL) → Z16.12
  • Resistance, resistant (to)organism(s)todrugcarbapenem → Z16.13
  • Resistance, resistant (to)organism(s)todrugcephalosporins → Z16.19
  • Resistance, resistant (to)organism(s)todrugantibiotic(s) → Z16.20
  • Resistance, resistant (to)organism(s)todrugvancomycin → Z16.21
  • Resistance, resistant (to)organism(s)todrugfluoroquinolones → Z16.23
  • Resistance, resistant (to)organism(s)todrugquinolones → Z16.23
  • Resistance, resistant (to)organism(s)todrugaminoglycosides → Z16.29
  • Resistance, resistant (to)organism(s)todrugmacrolides → Z16.29
  • Resistance, resistant (to)organism(s)todrugsulfonamides → Z16.29
  • Resistance, resistant (to)organism(s)todrugtetracyclines → Z16.29
  • Resistance, resistant (to)organism(s)todrugantimicrobial (single) → Z16.30
  • Resistance, resistant (to)organism(s)todrugantiparasitic → Z16.31
  • Resistance, resistant (to)organism(s)todrugquinine (and related compounds) → Z16.31
  • Resistance, resistant (to)organism(s)todrugantifungal → Z16.32
  • Resistance, resistant (to)organism(s)todrugantiviral → Z16.33
  • Resistance, resistant (to)organism(s)todrugantimycobacterial (single) → Z16.341
  • Resistance, resistant (to)organism(s)todrugtuberculostatics (single) → Z16.341
  • Resistance, resistant (to)organism(s)todrugbeta lactam antibioticsspecified NEC → Z16.19
  • Resistance, resistant (to)organism(s)todrugvancomycinrelated antibiotics → Z16.22
  • Resistance, resistant (to)organism(s)todrugantibiotic(s)multiple → Z16.24
  • Resistance, resistant (to)organism(s)todrugmultiple drugs (MDRO)antibiotics → Z16.24
  • Resistance, resistant (to)organism(s)todrugantibiotic(s)specified NEC → Z16.29
  • Resistance, resistant (to)organism(s)todrugantimycobacterial (single)multiple → Z16.342
  • Resistance, resistant (to)organism(s)todrugmultiple drugs (MDRO)antimycobacterials → Z16.342
  • Resistance, resistant (to)organism(s)todrugtuberculostatics (single)multiple → Z16.342
  • Resistance, resistant (to)organism(s)todrugantimicrobial (single)multiple → Z16.35
  • Resistance, resistant (to)organism(s)todrugmultiple drugs (MDRO)antimicrobial → Z16.35
  • Resistance, resistant (to)organism(s)todrugantimicrobial (single)specified NEC → Z16.39

NCHS Alphabetic Index. Index first, then the Tabular List.