DxCodebookFY2027 · Oct 1, 2026 – Sep 30, 2027

Category · FY2027

Z79 Long term (current) drug therapy

  • Header · not billable

Z79 is not billable. The category heads 32 billable codes in FY2027, grouped under 8 subdivisions.

Index → code

  • Prophylacticmedication → Z79.899
  • Long-term (current) (prophylactic) drug therapy (use of)Evista → Z79.810
  • Long-term (current) (prophylactic) drug therapy (use of)aspirin → Z79.82

Where it sits

  1. Chapter 21 Factors influencing health status and contact with health services (Z00-Z99)
  2. Z77-Z99 Persons with potential health hazards related to family and personal history and certain conditions influencing health status (Z77-Z99)
  3. Z79 Long term (current) drug therapy
Billable codes
32
Subdivisions
8
CC / MCC codes
0 / 0
HCC V28 codes
1
New FY2027
0
Index entries
127

Codes in Z79

  1. Z79.0
    Long term (current) use of anticoagulants and antithrombotics/antiplatelets
    Header
    Excludes2 1

    Excludes2

    • long term (current) use of aspirin (Z79.82) Z79.82
  2. Z79.01
    Long term (current) use of anticoagulants
    BillableExempt
  3. Z79.02
    Long term (current) use of antithrombotics/antiplatelets
    BillableExempt
  4. Z79.1
    Long term (current) use of non-steroidal anti-inflammatories (NSAID)
    BillableExempt
    Excludes2 1

    Excludes2

    • long term (current) use of aspirin (Z79.82) Z79.82
  5. Z79.2
    Long term (current) use of antibiotics
    BillableExempt
  6. Z79.3
    Long term (current) use of hormonal contraceptives
    BillableExempt
    Inclusion terms 1

    Inclusion terms

    • Long term (current) use of birth control pill or patch
  7. Z79.4
    Long term (current) use of insulin
    Billable38Exempt
    Excludes2 3

    Excludes2

    • long-term (current) use of injectable non-insulin antidiabetic drugs (Z79.85) Z79.85
    • long term (current) use of oral antidiabetic drugs (Z79.84) Z79.84
    • long term (current) use of oral hypoglycemic drugs (Z79.84) Z79.84
  8. Z79.5
    Long term (current) use of steroids
    Header
  9. Z79.51
    Long term (current) use of inhaled steroids
    BillableExempt
  10. Z79.52
    Long term (current) use of systemic steroids
    BillableExempt
  11. Z79.6
    Long term (current) use of immunomodulators and immunosuppressants
    Header
    Excludes2 2

    Excludes2

    • long term (current) use of steroids (Z79.5-) Z79.5
    • long term (current) use of agents affecting estrogen receptors and estrogen levels (Z79.81-) Z79.81
  12. Z79.60
    Long term (current) use of unspecified immunomodulators and immunosuppressants
    BillableExempt
  13. Z79.61
    Long term (current) use of immunomodulator
    BillableExempt
    Inclusion terms 4

    Inclusion terms

    • Long term (current) use of apremilast
    • Long term (current) use of immunomodulatory imide drug
    • Long term (current) use of lenalidomide
    • Long term (current) use of pomalidomide
  14. Z79.62
    Long term (current) use of immunosuppressant
    Header
  15. Z79.620
    Long term (current) use of immunosuppressive biologic
    BillableExempt
    Inclusion terms 4

    Inclusion terms

    • Long term (current) use of adalimumab
    • Long term (current) use of etanercept
    • Long term (current) use of infliximab
    • Long term (current) use of monoclonal antibodies
  16. Z79.621
    Long term (current) use of calcineurin inhibitor
    BillableExempt
    Inclusion terms 2

    Inclusion terms

    • Long term (current) use of cyclosporine
    • Long term (current) use of tacrolimus
  17. Z79.622
    Long term (current) use of Janus kinase inhibitor
    BillableExempt
    Inclusion terms 1

    Inclusion terms

    • Long term (current) use of tofacitinib
  18. Z79.623
    Long term (current) use of mammalian target of rapamycin (mTOR) inhibitor
    BillableExempt
    Inclusion terms 1

    Inclusion terms

    • Long term (current) use of sirolimus
  19. Z79.624
    Long term (current) use of inhibitors of nucleotide synthesis
    BillableExempt
    Inclusion terms 3

    Inclusion terms

    • Long term (current) use of azathioprine
    • Long term (current) use of mycophenolate
    • Long term (current) use of purine synthesis (IMDH) inhibitors
  20. Z79.63
    Long term (current) use of chemotherapeutic agent
    Header
  21. Z79.630
    Long term (current) use of alkylating agent
    BillableExempt
    Inclusion terms 3

    Inclusion terms

    • Long term (current) use of chlorambucil
    • Long term (current) use of cisplatin
    • Long term (current) use of cyclophosphamide
  22. Z79.631
    Long term (current) use of antimetabolite agent
    BillableExempt
    Inclusion terms 4

    Inclusion terms

    • Long term (current) use of 5-fluorouracil
    • Long term (current) use of 6-mercaptopurine
    • Long term (current) use of cytarabine
    • Long term (current) use of methotrexate
  23. Z79.632
    Long term (current) use of antitumor antibiotic
    BillableExempt
    Inclusion terms 3

    Inclusion terms

    • Long term (current) use of bleomycin
    • Long term (current) use of doxorubicin
    • Long term (current) use of mitomycin C
  24. Z79.633
    Long term (current) use of mitotic inhibitor
    BillableExempt
    Inclusion terms 4

    Inclusion terms

    • Long term (current) use of paclitaxel
    • Long term (current) use of plant alkaloids
    • Long term (current) use of vinblastine
    • Long term (current) use of vincristine
  25. Z79.634
    Long term (current) use of topoisomerase inhibitor
    BillableExempt
    Inclusion terms 3

    Inclusion terms

    • Long term (current) use of etoposide
    • Long term (current) use of irinotecan
    • Long term (current) use of topotecan
  26. Z79.64
    Long term (current) use of myelosuppressive agent
    BillableExempt
    Inclusion terms 1

    Inclusion terms

    • Long term (current) use of hydroxyurea
  27. Z79.69
    Long term (current) use of other immunomodulators and immunosuppressants
    BillableExempt
  28. Z79.8
    Other long term (current) drug therapy
    Header
  29. Z79.81
    Long term (current) use of agents affecting estrogen receptors and estrogen levels
    Header
    Excludes1 1, Code first 3, Use additional code 7

    Excludes1

    • hormone replacement therapy (Z79.890) Z79.890

    Code first

    • , if applicable:
    • malignant neoplasm of breast (C50.-) C50
    • malignant neoplasm of prostate (C61) C61

    Use additional code

    • code, if applicable, to identify:
    • estrogen receptor positive status (Z17.0) Z17.0
    • family history of breast cancer (Z80.3) Z80.3
    • genetic susceptibility to malignant neoplasm (cancer) (Z15.0-) Z15.0
    • personal history of breast cancer (Z85.3) Z85.3
    • personal history of prostate cancer (Z85.46) Z85.46
    • postmenopausal status (Z78.0) Z78.0
  30. Z79.810
    Long term (current) use of selective estrogen receptor modulators (SERMs)
    BillableExempt
    Inclusion terms 3

    Inclusion terms

    • Long term (current) use of raloxifene (Evista)
    • Long term (current) use of tamoxifen (Nolvadex)
    • Long term (current) use of toremifene (Fareston)
  31. Z79.811
    Long term (current) use of aromatase inhibitors
    BillableExempt
    Inclusion terms 3

    Inclusion terms

    • Long term (current) use of anastrozole (Arimidex)
    • Long term (current) use of exemestane (Aromasin)
    • Long term (current) use of letrozole (Femara)
  32. Z79.818
    Long term (current) use of other agents affecting estrogen receptors and estrogen levels
    BillableExempt
    Inclusion terms 6

    Inclusion terms

    • Long term (current) use of estrogen receptor downregulators
    • Long term (current) use of fulvestrant (Faslodex)
    • Long term (current) use of gonadotropin-releasing hormone (GnRH) agonist
    • Long term (current) use of goserelin acetate (Zoladex)
    • Long term (current) use of leuprolide acetate (leuprorelin) (Lupron)
    • Long term (current) use of megestrol acetate (Megace)
  33. Z79.82
    Long term (current) use of aspirin
    BillableExempt
  34. Z79.83
    Long term (current) use of bisphosphonates
    BillableExempt
  35. Z79.84
    Long term (current) use of oral hypoglycemic drugs
    BillableExempt
    Inclusion terms 1, Excludes2 2

    Inclusion terms

    • Long term (current) use of oral antidiabetic drugs

    Excludes2

    • long-term (current) use of injectable non-insulin antidiabetic drugs (Z79.85) Z79.85
    • long term (current) use of insulin (Z79.4) Z79.4
  36. Z79.85
    Long-term (current) use of injectable non-insulin antidiabetic drugs
    BillableExempt
    Excludes2 2

    Excludes2

    • long term (current) use of insulin (Z79.4) Z79.4
    • long term (current) use of oral hypoglycemic drugs (Z79.84) Z79.84
  37. Z79.89
    Other long term (current) drug therapy
    Header
  38. Z79.890
    Hormone replacement therapy
    BillableExempt
  39. Z79.891
    Long term (current) use of opiate analgesic
    BillableExempt
    Inclusion terms 1, Excludes2 2

    Inclusion terms

    • Long term (current) use of methadone for pain management

    Excludes2

    • methadone use NOS (F11.9-) F11.9
    • use of methadone for treatment of heroin addiction (F11.2-) F11.2
  40. Z79.899
    Other long term (current) drug therapy
    BillableExempt

Sources of each column.

Instructions

At Z79

Includes

  • long term (current) drug use for prophylactic purposes

Excludes2

  • drug abuse and dependence (F11-F19) F11 F19
  • drug use complicating pregnancy, childbirth, and the puerperium (O99.32-) O99.32

Code also

  • any therapeutic drug level monitoring (Z51.81) Z51.81

Notes that also apply

Block Z77-Z99 instructions (Code also 1): printed on the block page.

Chapter 21 instructions (Notes 3): printed on the chapter 21 page.

Index entries

  • Long-term (current) (prophylactic) drug therapy (use of)anticoagulants → Z79.01
  • Long-term (current) (prophylactic) drug therapy (use of)antiplatelet → Z79.02
  • Long-term (current) (prophylactic) drug therapy (use of)antithrombotics → Z79.02
  • Long-term (current) (prophylactic) drug therapy (use of)anti-inflammatory, non-steroidal (NSAID) → Z79.1
  • Long-term (current) (prophylactic) drug therapy (use of)non-steroidal anti-inflammatories (NSAID) → Z79.1
  • Long-term (current) (prophylactic) drug therapy (use of)antibiotics → Z79.2
  • Long-term (current) (prophylactic) drug therapy (use of)birth control pill or patch → Z79.3
  • Long-term (current) (prophylactic) drug therapy (use of)contraceptive, oral → Z79.3
  • Long-term (current) (prophylactic) drug therapy (use of)insulin → Z79.4
  • Long-term (current) (prophylactic) drug therapy (use of)immunomodulators, unspecified → Z79.60
  • Long-term (current) (prophylactic) drug therapy (use of)immunosuppressants, unspecified → Z79.60
  • Long-term (current) (prophylactic) drug therapy (use of)apremilast → Z79.61
  • Long-term (current) (prophylactic) drug therapy (use of)immunomodulatory imide drug → Z79.61
  • Long-term (current) (prophylactic) drug therapy (use of)lenalidomide → Z79.61
  • Long-term (current) (prophylactic) drug therapy (use of)pomalidomide → Z79.61
  • Long-term (current) (prophylactic) drug therapy (use of)adalimumab → Z79.620
  • Long-term (current) (prophylactic) drug therapy (use of)etanercept → Z79.620
  • Long-term (current) (prophylactic) drug therapy (use of)immunosuppressive biologic → Z79.620
  • Long-term (current) (prophylactic) drug therapy (use of)infliximab → Z79.620
  • Long-term (current) (prophylactic) drug therapy (use of)monoclonal antibodies → Z79.620
  • Long-term (current) (prophylactic) drug therapy (use of)calcineurin inhibitor → Z79.621
  • Long-term (current) (prophylactic) drug therapy (use of)cyclosporine → Z79.621
  • Long-term (current) (prophylactic) drug therapy (use of)tacrolimus → Z79.621
  • Long-term (current) (prophylactic) drug therapy (use of)Janus kinase inhibitor → Z79.622
  • Long-term (current) (prophylactic) drug therapy (use of)tofacitinib → Z79.622
  • Long-term (current) (prophylactic) drug therapy (use of)mammalian target of rapamycin (mTOR) inhibitor → Z79.623
  • Long-term (current) (prophylactic) drug therapy (use of)sirolimus → Z79.623
  • Long-term (current) (prophylactic) drug therapy (use of)azathioprine → Z79.624
  • Long-term (current) (prophylactic) drug therapy (use of)inhibitors of nucleotide synthesis → Z79.624
  • Long-term (current) (prophylactic) drug therapy (use of)mycophenolate → Z79.624
  • Long-term (current) (prophylactic) drug therapy (use of)purine synthesis (IMDH) inhibitors → Z79.624
  • Long-term (current) (prophylactic) drug therapy (use of)alkylating agent → Z79.630
  • Long-term (current) (prophylactic) drug therapy (use of)chlorambucil → Z79.630
  • Long-term (current) (prophylactic) drug therapy (use of)cisplatin → Z79.630
  • Long-term (current) (prophylactic) drug therapy (use of)cyclophosphamide → Z79.630
  • Long-term (current) (prophylactic) drug therapy (use of)5-fluorouracil → Z79.631
  • Long-term (current) (prophylactic) drug therapy (use of)6-mercaptopurine → Z79.631
  • Long-term (current) (prophylactic) drug therapy (use of)antimetabolite agent → Z79.631
  • Long-term (current) (prophylactic) drug therapy (use of)cytarabine → Z79.631
  • Long-term (current) (prophylactic) drug therapy (use of)antitumor antibiotic → Z79.632

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