DxCodebookFY2027 · Oct 1, 2026 – Sep 30, 2027

Category · FY2027

D56 Thalassemia

  • Header · not billable

D56 is not billable. The category heads 8 billable codes in FY2027: the 8 codes directly below it.

Index → code

  • Cooley's anemia → D56.1
  • Variants, thalassemic → D56.8
  • Leptocytosis, hereditary → D56.9

Where it sits

  1. Chapter 3 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
  2. D55-D59 Hemolytic anemias (D55-D59)
  3. D56 Thalassemia
Billable codes
8
Subdivisions
8
CC / MCC codes
0 / 0
HCC V28 codes
3
New FY2027
0
Index entries
58

Codes in D56

  1. D56.0
    Alpha thalassemia
    Billable
    Inclusion terms 6, Excludes1 4, Use additional code 1

    Inclusion terms

    • Alpha thalassemia major
    • Hemoglobin H Constant Spring
    • Hemoglobin H disease
    • Hydrops fetalis due to alpha thalassemia
    • Severe alpha thalassemia
    • Triple gene defect alpha thalassemia

    Excludes1

    • alpha thalassemia trait or minor (D56.3) D56.3
    • asymptomatic alpha thalassemia (D56.3) D56.3
    • hydrops fetalis due to isoimmunization (P56.0) P56.0
    • hydrops fetalis not due to immune hemolysis (P83.2) P83.2

    Use additional code

    • code, if applicable, for hydrops fetalis due to alpha thalassemia (P56.99) P56.99
  2. D56.1
    Beta thalassemia
    Billable108
    Inclusion terms 6, Excludes1 5

    Inclusion terms

    • Beta thalassemia major
    • Cooley's anemia
    • Homozygous beta thalassemia
    • Severe beta thalassemia
    • Thalassemia intermedia
    • Thalassemia major

    Excludes1

    • beta thalassemia minor (D56.3) D56.3
    • beta thalassemia trait (D56.3) D56.3
    • delta-beta thalassemia (D56.2) D56.2
    • hemoglobin E-beta thalassemia (D56.5) D56.5
    • sickle-cell beta thalassemia (D57.4-) D57.4
  3. D56.2
    Delta-beta thalassemia
    Billable108
    Inclusion terms 1, Excludes1 2

    Inclusion terms

    • Homozygous delta-beta thalassemia

    Excludes1

    • delta-beta thalassemia minor (D56.3) D56.3
    • delta-beta thalassemia trait (D56.3) D56.3
  4. D56.3
    Thalassemia minor
    Billable
    Inclusion terms 8, Excludes1 5

    Inclusion terms

    • Alpha thalassemia minor
    • Alpha thalassemia silent carrier
    • Alpha thalassemia trait
    • Beta thalassemia minor
    • Beta thalassemia trait
    • Delta-beta thalassemia minor
    • Delta-beta thalassemia trait
    • Thalassemia trait NOS

    Excludes1

    • alpha thalassemia (D56.0) D56.0
    • beta thalassemia (D56.1) D56.1
    • delta-beta thalassemia (D56.2) D56.2
    • hemoglobin E-beta thalassemia (D56.5) D56.5
    • sickle-cell trait (D57.3) D57.3
  5. D56.4
    Hereditary persistence of fetal hemoglobin [HPFH]
    Billable
  6. D56.5
    Hemoglobin E-beta thalassemia
    Billable108
    Excludes1 8

    Excludes1

    • beta thalassemia (D56.1) D56.1
    • beta thalassemia minor (D56.3) D56.3
    • beta thalassemia trait (D56.3) D56.3
    • delta-beta thalassemia (D56.2) D56.2
    • delta-beta thalassemia trait (D56.3) D56.3
    • hemoglobin E disease (D58.2) D58.2
    • other hemoglobinopathies (D58.2) D58.2
    • sickle-cell beta thalassemia (D57.4-) D57.4
  7. D56.8
    Other thalassemias
    Billable
    Inclusion terms 4, Excludes1 5

    Inclusion terms

    • Dominant thalassemia
    • Hemoglobin C thalassemia
    • Mixed thalassemia
    • Thalassemia with other hemoglobinopathy

    Excludes1

    • hemoglobin C disease (D58.2) D58.2
    • hemoglobin E disease (D58.2) D58.2
    • other hemoglobinopathies (D58.2) D58.2
    • sickle-cell anemia (D57.-) D57
    • sickle-cell thalassemia (D57.4-) D57.4
  8. D56.9
    Thalassemia, unspecified
    Billable
    Inclusion terms 1

    Inclusion terms

    • Mediterranean anemia (with other hemoglobinopathy)

Sources of each column.

Instructions

At D56

Excludes1

  • sickle-cell thalassemia (D57.4-) D57.4

Notes that also apply

Chapter 3 instructions (Excludes2 9): printed on the chapter 3 page.

Index entries

  • Cooley's anemia → D56.1
  • Variants, thalassemic → D56.8
  • Leptocytosis, hereditary → D56.9
  • Rietti-Greppi-Micheli anemia → D56.9
  • Thalassemia (anemia) (disease) → D56.9
  • Hb (abnormal)Bart's disease → D56.0
  • HemoglobinH Constant Spring → D56.0
  • Thalassemia (anemia) (disease)alpha (major) (severe) (triple gene defect) → D56.0
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)Cooley's (erythroblastic) → D56.1
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)familial erythroblastic → D56.1
  • Thalassemia (anemia) (disease)beta (severe) → D56.1
  • Thalassemia (anemia) (disease)intermedia → D56.1
  • Thalassemia (anemia) (disease)major → D56.1
  • Thalassemia (anemia) (disease)delta-beta (homozygous) → D56.2
  • Thalassemia (anemia) (disease)minor → D56.3
  • Thalassemia (anemia) (disease)trait → D56.3
  • Trait(s)Lepore → D56.3
  • Hemoglobinfetal, hereditary persistence (HPFH) → D56.4
  • Persistence, persistent (congenital)hemoglobin, fetal (hereditary) (HPFH) → D56.4
  • HemoglobinE-beta thalassemia → D56.5
  • Hemoglobinopathy (mixed)with thalassemia → D56.8
  • Thalassemia (anemia) (disease)with other hemoglobinopathy → D56.8
  • Thalassemia (anemia) (disease)dominant → D56.8
  • Thalassemia (anemia) (disease)mixed → D56.8
  • Thalassemia (anemia) (disease)specified type NEC → D56.8
  • Thalassemia (anemia) (disease)variants → D56.8
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)Mediterranean (with other hemoglobinopathy) → D56.9
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)microelliptopoikilocytic (Rietti-Greppi- Micheli) → D56.9
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)Rietti-Greppi-Micheli → D56.9
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)thalassemia → D56.9
  • Disease, diseasedhigh fetal gene or hemoglobin thalassemia → D56.9
  • Disease, diseasedhemoglobin or HbBart's → D56.0
  • Disease, diseasedhemoglobin or HbH (Hb-H) (thalassemia) → D56.0
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)erythroblasticfamilial → D56.1
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)erythroblasticof childhood → D56.1
  • Thalassemia (anemia) (disease)beta (severe)homozygous → D56.1
  • Thalassemia (anemia) (disease)beta (severe)major → D56.1
  • Thalassemia (anemia) (disease)alpha (major) (severe) (triple gene defect)minor → D56.3
  • Thalassemia (anemia) (disease)alpha (major) (severe) (triple gene defect)silent carrier → D56.3
  • Thalassemia (anemia) (disease)alpha (major) (severe) (triple gene defect)trait → D56.3

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