DxCodebookFY2027 · Oct 1, 2026 – Sep 30, 2027

Category · FY2027

D57 Sickle-cell disorders

  • Header · not billable

D57 is not billable. The category heads 43 billable codes in FY2027, grouped under 6 subdivisions.

Index → code

  • Microdrepanocytosis → D57.40
  • Trait(s)Hb-S → D57.3
  • Sicklemiatrait → D57.3

Where it sits

  1. Chapter 3 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
  2. D55-D59 Hemolytic anemias (D55-D59)
  3. D57 Sickle-cell disorders
Billable codes
43
Subdivisions
6
CC / MCC codes
0 / 36
HCC V28 codes
42
New FY2027
0
Index entries
185

Codes in D57

  1. D57.0
    Hb-SS disease with crisis
    Header
    Inclusion terms 2

    Inclusion terms

    • Sickle-cell disease with crisis
    • Hb-SS disease with (vaso-occlusive) pain
  2. D57.00
    Hb-SS disease with crisis, unspecified
    BillableMCC107
    Inclusion terms 2

    Inclusion terms

    • Hb-SS disease with (painful) crisis NOS
    • Hb-SS disease with (vaso-occlusive) pain NOS
  3. D57.01
    Hb-SS disease with acute chest syndrome
    BillableMCC107
  4. D57.02
    Hb-SS disease with splenic sequestration
    BillableMCC107
  5. D57.03
    Hb-SS disease with cerebral vascular involvement
    BillableMCC107
    Code also 1

    Code also

    • , if applicable, cerebral infarction (I63.-) I63
  6. D57.04
    Hb-SS disease with dactylitis
    BillableMCC107
  7. D57.09
    Hb-SS disease with crisis with other specified complication
    BillableMCC107
    Use additional code 3

    Use additional code

    • code to identify complications, such as:
    • cholelithiasis (K80.-) K80
    • priapism (N48.32) N48.32
  8. D57.1
    Sickle-cell disease without crisis
    Billable107
    Inclusion terms 4

    Inclusion terms

    • Hb-SS disease without crisis
    • Sickle-cell anemia NOS
    • Sickle-cell disease NOS
    • Sickle-cell disorder NOS
  9. D57.2
    Sickle-cell/Hb-C disease
    Header
    Inclusion terms 2

    Inclusion terms

    • Hb-SC disease
    • Hb-S/Hb-C disease
  10. D57.20
    Sickle-cell/Hb-C disease without crisis
    Billable108
  11. D57.21
    Sickle-cell/Hb-C disease with crisis
    Header
  12. D57.211
    Sickle-cell/Hb-C disease with acute chest syndrome
    BillableMCC108
  13. D57.212
    Sickle-cell/Hb-C disease with splenic sequestration
    BillableMCC108
  14. D57.213
    Sickle-cell/Hb-C disease with cerebral vascular involvement
    BillableMCC108
    Code also 1

    Code also

    • , if applicable, cerebral infarction (I63.-) I63
  15. D57.214
    Sickle-cell/Hb-C disease with dactylitis
    BillableMCC108
  16. D57.218
    Sickle-cell/Hb-C disease with crisis with other specified complication
    BillableMCC108
    Use additional code 3

    Use additional code

    • code to identify complications, such as:
    • cholelithiasis (K80.-) K80
    • priapism (N48.32) N48.32
  17. D57.219
    Sickle-cell/Hb-C disease with crisis, unspecified
    BillableMCC108
    Inclusion terms 2

    Inclusion terms

    • Sickle-cell/Hb-C disease with crisis NOS
    • Sickle-cell/Hb-C disease with (vaso-occlusive) pain NOS
  18. D57.3
    Sickle-cell trait
    Billable
    Inclusion terms 2

    Inclusion terms

    • Hb-S trait
    • Heterozygous hemoglobin S
  19. D57.4
    Sickle-cell thalassemia
    Header
    Inclusion terms 2

    Inclusion terms

    • Sickle-cell beta thalassemia
    • Thalassemia Hb-S disease
  20. D57.40
    Sickle-cell thalassemia without crisis
    Billable108
    Inclusion terms 2

    Inclusion terms

    • Microdrepanocytosis
    • Sickle-cell thalassemia NOS
  21. D57.41
    Sickle-cell thalassemia, unspecified, with crisis
    Header
    Inclusion terms 2

    Inclusion terms

    • Sickle-cell thalassemia with (painful) crisis NOS
    • Sickle-cell thalassemia with (vaso-occlusive) pain NOS
  22. D57.411
    Sickle-cell thalassemia, unspecified, with acute chest syndrome
    BillableMCC108
  23. D57.412
    Sickle-cell thalassemia, unspecified, with splenic sequestration
    BillableMCC108
  24. D57.413
    Sickle-cell thalassemia, unspecified, with cerebral vascular involvement
    BillableMCC108
    Code also 1

    Code also

    • , if applicable cerebral infarction (I63.-) I63
  25. D57.414
    Sickle-cell thalassemia, unspecified, with dactylitis
    BillableMCC108
  26. D57.418
    Sickle-cell thalassemia, unspecified, with crisis with other specified complication
    BillableMCC108
    Use additional code 3

    Use additional code

    • code to identify complications, such as:
    • cholelithiasis (K80.-) K80
    • priapism (N48.32) N48.32
  27. D57.419
    Sickle-cell thalassemia, unspecified, with crisis
    BillableMCC108
    Inclusion terms 2

    Inclusion terms

    • Sickle-cell thalassemia with (painful) crisis NOS
    • Sickle-cell thalassemia with (vaso-occlusive) pain NOS
  28. D57.42
    Sickle-cell thalassemia beta zero without crisis
    Billable107
    Inclusion terms 2

    Inclusion terms

    • HbS-beta zero without crisis
    • Sickle-cell beta zero without crisis
  29. D57.43
    Sickle-cell thalassemia beta zero with crisis
    Header
    Inclusion terms 2

    Inclusion terms

    • HbS-beta zero with crisis
    • Sickle-cell beta zero with crisis
  30. D57.431
    Sickle-cell thalassemia beta zero with acute chest syndrome
    BillableMCC107
    Inclusion terms 2

    Inclusion terms

    • HbS-beta zero with acute chest syndrome
    • Sickle-cell beta zero with acute chest syndrome
  31. D57.432
    Sickle-cell thalassemia beta zero with splenic sequestration
    BillableMCC107
    Inclusion terms 2

    Inclusion terms

    • HbS-beta zero with splenic sequestration
    • Sickle-cell beta zero with splenic sequestration
  32. D57.433
    Sickle-cell thalassemia beta zero with cerebral vascular involvement
    BillableMCC107
    Inclusion terms 2, Code also 1

    Inclusion terms

    • HbS-beta zero with cerebral vascular involvement
    • Sickle-cell beta zero with cerebral vascular involvement

    Code also

    • , if applicable cerebral infarction (I63.-) I63
  33. D57.434
    Sickle-cell thalassemia beta zero with dactylitis
    BillableMCC107
  34. D57.438
    Sickle-cell thalassemia beta zero with crisis with other specified complication
    BillableMCC107
    Inclusion terms 2, Use additional code 3

    Inclusion terms

    • HbS-beta zero with other specified complication
    • Sickle-cell beta zero with other specified complication

    Use additional code

    • code to identify complications, such as:
    • cholelithiasis (K80.-) K80
    • priapism (N48.32) N48.32
  35. D57.439
    Sickle-cell thalassemia beta zero with crisis, unspecified
    BillableMCC107
    Inclusion terms 4

    Inclusion terms

    • HbS-beta zero with other specified complication
    • Sickle-cell beta zero with crisis unspecified
    • Sickle-cell thalassemia beta zero with (painful) crisis NOS
    • Sickle-cell thalassemia beta zero with (vaso-occlusive) pain NOS
  36. D57.44
    Sickle-cell thalassemia beta plus without crisis
    Billable108
    Inclusion terms 2

    Inclusion terms

    • HbS-beta plus without crisis
    • Sickle-cell beta plus without crisis
  37. D57.45
    Sickle-cell thalassemia beta plus with crisis
    Header
    Inclusion terms 2

    Inclusion terms

    • HbS-beta plus with crisis
    • Sickle-cell beta plus with crisis
  38. D57.451
    Sickle-cell thalassemia beta plus with acute chest syndrome
    BillableMCC108
    Inclusion terms 2

    Inclusion terms

    • HbS-beta plus with acute chest syndrome
    • Sickle-cell beta plus with acute chest syndrome
  39. D57.452
    Sickle-cell thalassemia beta plus with splenic sequestration
    BillableMCC108
    Inclusion terms 2

    Inclusion terms

    • HbS-beta plus with splenic sequestration
    • Sickle-cell beta plus with splenic sequestration
  40. D57.453
    Sickle-cell thalassemia beta plus with cerebral vascular involvement
    BillableMCC108
    Inclusion terms 2, Code also 1

    Inclusion terms

    • HbS-beta plus with cerebral vascular involvement
    • Sickle-cell beta plus with cerebral vascular involvement

    Code also

    • , if applicable cerebral infarction (I63.-) I63
  41. D57.454
    Sickle-cell thalassemia beta plus with dactylitis
    BillableMCC108
  42. D57.458
    Sickle-cell thalassemia beta plus with crisis with other specified complication
    BillableMCC108
    Inclusion terms 2, Use additional code 3

    Inclusion terms

    • HbS-beta plus with crisis with other specified complication
    • Sickle-cell beta plus with crisis with other specified complication

    Use additional code

    • code to identify complications, such as:
    • cholelithiasis (K80.-) K80
    • priapism (N48.32) N48.32
  43. D57.459
    Sickle-cell thalassemia beta plus with crisis, unspecified
    BillableMCC108
    Inclusion terms 4

    Inclusion terms

    • HbS-beta plus with crisis with unspecified complication
    • Sickle-cell beta plus with crisis with unspecified complication
    • Sickle-cell thalassemia beta plus with (painful) crisis NOS
    • Sickle-cell thalassemia beta plus with (vaso-occlusive) pain NOS
  44. D57.8
    Other sickle-cell disorders
    Header
    Inclusion terms 2

    Inclusion terms

    • Hb-SD disease
    • Hb-SE disease
  45. D57.80
    Other sickle-cell disorders without crisis
    Billable108
  46. D57.81
    Other sickle-cell disorders with crisis
    Header
  47. D57.811
    Other sickle-cell disorders with acute chest syndrome
    BillableMCC108
  48. D57.812
    Other sickle-cell disorders with splenic sequestration
    BillableMCC108
  49. D57.813
    Other sickle-cell disorders with cerebral vascular involvement
    BillableMCC108
    Code also 1

    Code also

    • , if applicable: cerebral infarction (I63.-) I63
  50. D57.814
    Other sickle-cell disorders with dactylitis
    BillableMCC108
  51. D57.818
    Other sickle-cell disorders with crisis with other specified complication
    BillableMCC108
    Use additional code 3

    Use additional code

    • code to identify complications, such as:
    • cholelithiasis (K80.-) K80
    • priapism (N48.32) N48.32
  52. D57.819
    Other sickle-cell disorders with crisis, unspecified
    BillableMCC108
    Inclusion terms 2

    Inclusion terms

    • Other sickle-cell disorders with crisis NOS
    • Other sickle-cell disorders with (vaso-occlusive) pain NOS

CC/MCC: as a secondary diagnosis, unless the principal diagnosis is on the code’s PDX exclusion list (MS-DRG v44 Appendix C; list on the code card).

Sources of each column.

Instructions

At D57

Excludes1

  • other hemoglobinopathies (D58.-) D58

Use additional code

  • code for any associated fever (R50.81) R50.81

Notes that also apply

Chapter 3 instructions (Excludes2 9): printed on the chapter 3 page.

Index entries

  • Microdrepanocytosis → D57.40
  • Nephropathysickle-cell → D57.- [N08]
  • Crisissickle-cell → D57.00
  • Dactylitissickle-cell → D57.04
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)Herrick's → D57.1
  • Disease, diseasedsickle-cell → D57.1
  • Hemoglobinopathy (mixed)sickle-cell → D57.1
  • HemoglobinAS genotype → D57.3
  • HemoglobinS (Hb S), heterozygous → D57.3
  • Sickle-celltrait → D57.3
  • Sicklemiatrait → D57.3
  • Trait(s)Hb-S → D57.3
  • Trait(s)sickle-cell → D57.3
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)microdrepanocytosis → D57.40
  • Elliptocytosis (congenital) (hereditary)sickle-cell (disease) → D57.8-
  • Spherocytosis (congenital) (familial) (hereditary)sickle-cell (disease) → D57.8-
  • Disorder (of)glomerular (in)sickle-cell disorders → D57.- [N08]
  • Glomerulonephritisin (due to)sickle-cell disorders → D57.- [N08]
  • Retinopathy (background)proliferative NECsickle-cell → D57.- [H36.82-]
  • Dactylitissickle-cellHb SS → D57.04
  • Disease, diseasedhemoglobin or HbS or SS → D57.1
  • Disease, diseasedhemoglobin or HbSC → D57.2-
  • Disease, diseasedsickle-cellHb-C → D57.20
  • Dactylitissickle-cellHb C → D57.214
  • Disease, diseasedhemoglobin or HbAS genotype → D57.3
  • Disorder (of)sickle-cell (sickling) (homozygous)heterozygous → D57.3
  • Disorder (of)sickle-cell (sickling) (homozygous)trait → D57.3
  • Elliptocytosis (congenital) (hereditary)sickle-cell (disease)trait → D57.3
  • Trait(s)hemoglobinS (Hb-S) → D57.3
  • Trait(s)sickle-cellwith elliptocytosis or spherocytosis → D57.3
  • Disease, diseasedsickle-cellthalassemia → D57.40
  • Hemoglobinopathy (mixed)sickle-cellwith thalassemia → D57.40
  • Microdrepanocytosiswithacute chest syndrome → D57.411
  • Microdrepanocytosiswithsplenic sequestration → D57.412
  • Microdrepanocytosiswithcerebral vascular involvement → D57.413
  • Dactylitissickle-cellthalassemia → D57.414
  • Microdrepanocytosiswithcrisis (painful) → D57.419
  • Microdrepanocytosiswithpain (vaso-occlusive) → D57.419
  • Dactylitissickle-cellBeta zero → D57.434
  • Dactylitissickle-cellBeta plus → D57.454

145 more, longer entries are not listed; the search box finds them by word.

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