DxCodebookFY2027 · Oct 1, 2026 – Sep 30, 2027

Category · FY2027

D59 Acquired hemolytic anemia

  • Header · not billable

D59 is not billable. The category heads 16 billable codes in FY2027, grouped under 9 subdivisions.

Index → code

  • Hemoglobinemia → D59.9
  • Abrami's disease → D59.8
  • Harley's disease → D59.6

Where it sits

  1. Chapter 3 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
  2. D55-D59 Hemolytic anemias (D55-D59)
  3. D59 Acquired hemolytic anemia
Billable codes
16
Subdivisions
9
CC / MCC codes
9 / 4
HCC V28 codes
14
New FY2027
0
Index entries
109

Codes in D59

  1. D59.0
    Drug-induced autoimmune hemolytic anemia
    BillableCC
    Use additional code 1

    Use additional code

    • code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5) T36 T50
  2. D59.1
    Other autoimmune hemolytic anemias
    Header
    Excludes2 3

    Excludes2

    • Evans syndrome (D69.41) D69.41
    • hemolytic disease of newborn (P55.-) P55
    • paroxysmal cold hemoglobinuria (D59.6) D59.6
  3. D59.10
    Autoimmune hemolytic anemia, unspecified
    BillableCC109
  4. D59.11
    Warm autoimmune hemolytic anemia
    BillableCC109
    Inclusion terms 2

    Inclusion terms

    • Warm type (primary) (secondary) (symptomatic) autoimmune hemolytic anemia
    • Warm type autoimmune hemolytic disease
  5. D59.12
    Cold autoimmune hemolytic anemia
    BillableCC109
    Inclusion terms 5

    Inclusion terms

    • Chronic cold hemagglutinin disease
    • Cold agglutinin disease
    • Cold agglutinin hemoglobinuria
    • Cold type (primary) (secondary) (symptomatic) autoimmune hemolytic anemia
    • Cold type autoimmune hemolytic disease
  6. D59.13
    Mixed type autoimmune hemolytic anemia
    BillableCC109
    Inclusion terms 2

    Inclusion terms

    • Mixed type autoimmune hemolytic disease
    • Mixed type, cold and warm, (primary) (secondary) (symptomatic) autoimmune hemolytic anemia
  7. D59.19
    Other autoimmune hemolytic anemia
    BillableCC109
  8. D59.2
    Drug-induced nonautoimmune hemolytic anemia
    BillableCC
    Inclusion terms 1, Use additional code 1

    Inclusion terms

    • Drug-induced enzyme deficiency anemia

    Use additional code

    • code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5) T36 T50
  9. D59.3
    Hemolytic-uremic syndrome
    Header
    Code also 3

    Code also

    • , if applicable, any associated:
    • acute kidney failure (N17.-) N17
    • chronic kidney disease (N18.-) N18
  10. D59.30
    Hemolytic-uremic syndrome, unspecified
    BillableMCC109
    Inclusion terms 1

    Inclusion terms

    • Hemolytic-uremic syndrome NOS
  11. D59.31
    Infection-associated hemolytic-uremic syndrome
    BillableMCC109
    Inclusion terms 2, Use additional code 8

    Inclusion terms

    • Shiga toxin-producing E. coli [STEC] related hemolytic uremic syndrome
    • Typical hemolytic uremic syndrome

    Use additional code

    • code to identify associated infection, such as :
    • E. coli infection (B96.2-) B96.2
    • Human immunodeficiency virus [HIV] disease (B20) B20
    • Pneumococcal meningitis (G00.1) G00.1
    • Pneumococcal pneumonia (J13) J13
    • Sepsis due to Streptococcus pneumoniae (A40.3) A40.3
    • Shigella dysenteriae (A03.9) A03.9
    • Streptococcus pneumoniae as the cause of diseases classified elsewhere (B95.3) B95.3
  12. D59.32
    Hereditary hemolytic-uremic syndrome
    BillableMCC109
    Inclusion terms 1, Code also 3

    Inclusion terms

    • Atypical hemolytic uremic syndrome with an identified genetic cause

    Code also

    • , if applicable:
    • defects in the complement system (D84.1) D84.1
    • methylmalonic acidemia (E71.120) E71.120
  13. D59.39
    Other hemolytic-uremic syndrome
    BillableMCC109
    Inclusion terms 2, Code first 5, Use additional code 1, Code also 4

    Inclusion terms

    • Atypical (nongenetic) hemolytic uremic syndrome
    • Secondary hemolytic-uremic syndrome

    Code first

    • , if applicable, any associated:
    • COVID-19 (U07.1) U07.1
    • complications of kidney transplant (T86.1-) T86.1
    • complications of heart transplant (T86.2-) T86.2
    • complications of liver transplant (T86.4-) T86.4

    Use additional code

    • code, if applicable, for adverse effect to identify drug (T36-T50 with fifth or sixth character 5) T36 T50

    Code also

    • , if applicable, any associated condition, such as:
    • hypertensive emergency (I16.1) I16.1
    • malignant neoplasm (C00-C96) C00 C96
    • systemic lupus erythematosus (M32.-) M32
  14. D59.4
    Other nonautoimmune hemolytic anemias
    BillableCC109
    Inclusion terms 3

    Inclusion terms

    • Mechanical hemolytic anemia
    • Microangiopathic hemolytic anemia
    • Toxic hemolytic anemia
  15. D59.5
    Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]
    Billable109
    Excludes1 1

    Excludes1

    • hemoglobinuria NOS (R82.3) R82.3
  16. D59.6
    Hemoglobinuria due to hemolysis from other external causes
    Billable109
    Inclusion terms 3, Excludes1 1, Use additional code 1

    Inclusion terms

    • Hemoglobinuria from exertion
    • March hemoglobinuria
    • Paroxysmal cold hemoglobinuria

    Excludes1

    • hemoglobinuria NOS (R82.3) R82.3

    Use additional code

    • code (Chapter 20) to identify external cause
  17. D59.8
    Other acquired hemolytic anemias
    Billable109
  18. D59.9
    Acquired hemolytic anemia, unspecified
    BillableCC109
    Inclusion terms 1

    Inclusion terms

    • Idiopathic hemolytic anemia, chronic

CC/MCC: as a secondary diagnosis, unless the principal diagnosis is on the code’s PDX exclusion list (MS-DRG v44 Appendix C; list on the code card).

Sources of each column.

Instructions

Notes that also apply

Chapter 3 instructions (Excludes2 9): printed on the chapter 3 page.

Index entries

  • Dyke-Young anemia (secondary) (symptomatic) → D59.19
  • Lederer's anemia → D59.19
  • Nonautoimmune hemolytic anemia → D59.4
  • Marchiafava-Micheli syndrome → D59.5
  • Harley's disease → D59.6
  • Murri's disease (intermittent hemoglobinuria) → D59.6
  • Abrami's disease → D59.8
  • Hayem-Widal syndrome → D59.8
  • Hemoglobinemia → D59.9
  • Icteroanemia, hemolytic (acquired) → D59.9
  • Coldagglutinin disease or hemoglobinuria (chronic) → D59.12
  • Coldsensitivity, auto-immune → D59.12
  • Sensitive, sensitivitycold, autoimmune → D59.12
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)Dyke-Young type (secondary) (symptomatic) → D59.19
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)Lederer's (hemolytic) → D59.19
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)enzyme-deficiency, drug-induced → D59.2
  • Nonautoimmune hemolytic anemiadrug-induced → D59.2
  • Syndromehemolytic-uremic → D59.30
  • Disease, diseasednonautoimmune hemolytic → D59.4
  • Syndromeerythrocyte fragmentation → D59.4
  • Hemoglobinurianocturnal (paroxysmal) → D59.5
  • Hemoglobinemiaparoxysmal → D59.6
  • Hemoglobinuriawith anemia, hemolytic, acquired (chronic) NEC → D59.6
  • Hemoglobinuriacold (paroxysmal) (with Raynaud's syndrome) → D59.6
  • Hemoglobinuriadue to exertion or hemolysis NEC → D59.6
  • Hemoglobinuriaintermittent → D59.6
  • Hemoglobinuriamarch → D59.6
  • Hemoglobinuriaparoxysmal (cold) → D59.6
  • Marchhemoglobinuria → D59.6
  • Acholuric jaundice (familial) (splenomegalic)acquired → D59.8
  • Icterushematogenous (acquired) → D59.9
  • Icterushemolytic (acquired) → D59.9
  • Jaundice (yellow)hematogenous → D59.9
  • Jaundice (yellow)hemolytic (acquired) → D59.9
  • Disease, diseasedhemolytic (newborn)drug-induced → D59.0
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)hemolyticautoimmune → D59.10
  • Disease, diseasedautoimmune (systemic) NOShemolytic → D59.10
  • Disease, diseasedhemolytic (newborn)autoimmune → D59.10
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)hemolyticwarm type (primary) (secondary) (symptomatic) → D59.11
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)hemolyticcold type (primary) (secondary) (symptomatic) → D59.12

69 more, longer entries are not listed; the search box finds them by word.

NCHS Alphabetic Index. Index first, then the Tabular List.

Hierarchy